Hyposmia and executive dysfunction as predictors of future Parkinson's disease: A prospective study
Identifieur interne : 002266 ( Main/Exploration ); précédent : 002265; suivant : 002267Hyposmia and executive dysfunction as predictors of future Parkinson's disease: A prospective study
Auteurs : Mirthe M. Ponsen [Pays-Bas] ; Diederick Stoffers [Pays-Bas] ; Jos W. R. Twisk [Pays-Bas] ; Erik Ch. Wolters [Pays-Bas] ; Henk W. Berendse [Pays-Bas]Source :
- Movement Disorders [ 0885-3185 ] ; 2009-05-15.
Descripteurs français
- Pascal (Inist)
- Wicri :
- topic : Prospective.
English descriptors
- KwdEn :
- Aged, Asymptomatic, Cognition, Cognition Disorders (etiology), Cognitive disorder, Diagnosis, Family Health, Female, Humans, Longitudinal Studies, Male, Middle Aged, Nervous system diseases, Neurologic Examination, Neuropsychological Tests, Olfaction, Olfaction Disorders (complications), Olfactory disorder, Parkinson Disease (diagnosis), Parkinson Disease (etiology), Parkinson disease, Parkinson's disease, Predictive Value of Tests, Problem Solving (physiology), Prospective, Regression Analysis, cognition, early diagnosis, olfaction, preclinical period.
- MESH :
- complications : Olfaction Disorders.
- diagnosis : Parkinson Disease.
- etiology : Cognition Disorders, Parkinson Disease.
- physiology : Problem Solving.
- Aged, Family Health, Female, Humans, Longitudinal Studies, Male, Middle Aged, Neurologic Examination, Neuropsychological Tests, Predictive Value of Tests, Regression Analysis.
Abstract
Olfactory deficits and executive dysfunction are early and common symptoms in Parkinson's disease (PD). Previous studies have shown that hyposmia can be a first sign of PD. The aim of the present study was to determine which of three olfactory tests and two selected tests of executive function would be the best predictor of future PD over a 5 year period. In a cohort of 361 nonparkinsonian, nondemented first‐degree relatives of PD patients, in whom alternative causes of olfactory dysfunction were excluded, we measured baseline performance on three olfactory and two executive function tasks. Five years from baseline, clinical neurological evaluation and/or a screening questionnaire, sensitive to the presence of Parkinsonism, were used to detect individuals developing clinical PD. Our results show that in first degree relatives of PD patients worse performance on each of three olfactory processing tasks was associated with an increased risk of developing PD within 5 years, whereas performance on selected tests of executive dysfunction was not associated with an increased risk of developing PD. Interestingly, impaired odor discrimination was the best predictor for future PD. © 2009 Movement Disorder Society
Url:
DOI: 10.1002/mds.22534
Affiliations:
Links toward previous steps (curation, corpus...)
- to stream Istex, to step Corpus: 001C83
- to stream Istex, to step Curation: 001C83
- to stream Istex, to step Checkpoint: 000E68
- to stream PubMed, to step Corpus: 001D76
- to stream PubMed, to step Curation: 001D76
- to stream PubMed, to step Checkpoint: 001D72
- to stream Ncbi, to step Merge: 002601
- to stream Ncbi, to step Curation: 002601
- to stream Ncbi, to step Checkpoint: 002601
- to stream Main, to step Merge: 002B27
- to stream PascalFrancis, to step Corpus: 000E77
- to stream PascalFrancis, to step Curation: 001E42
- to stream PascalFrancis, to step Checkpoint: 000E45
- to stream Main, to step Merge: 002F42
- to stream Main, to step Curation: 002266
Le document en format XML
<record><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title xml:lang="en">Hyposmia and executive dysfunction as predictors of future Parkinson's disease: A prospective study</title><author><name sortKey="Ponsen, Mirthe M" sort="Ponsen, Mirthe M" uniqKey="Ponsen M" first="Mirthe M." last="Ponsen">Mirthe M. Ponsen</name></author><author><name sortKey="Stoffers, Diederick" sort="Stoffers, Diederick" uniqKey="Stoffers D" first="Diederick" last="Stoffers">Diederick Stoffers</name></author><author><name sortKey="Twisk, Jos W R" sort="Twisk, Jos W R" uniqKey="Twisk J" first="Jos W. R." last="Twisk">Jos W. R. Twisk</name></author><author><name sortKey="Wolters, Erik Ch" sort="Wolters, Erik Ch" uniqKey="Wolters E" first="Erik Ch." last="Wolters">Erik Ch. Wolters</name></author><author><name sortKey="Berendse, Henk W" sort="Berendse, Henk W" uniqKey="Berendse H" first="Henk W." last="Berendse">Henk W. Berendse</name></author></titleStmt><publicationStmt><idno type="wicri:source">ISTEX</idno><idno type="RBID">ISTEX:2BE542FF53E743C869DC1F5D9BBB5E50979EFEA0</idno><date when="2009" year="2009">2009</date><idno type="doi">10.1002/mds.22534</idno><idno type="url">https://api.istex.fr/document/2BE542FF53E743C869DC1F5D9BBB5E50979EFEA0/fulltext/pdf</idno><idno type="wicri:Area/Istex/Corpus">001C83</idno><idno type="wicri:Area/Istex/Curation">001C83</idno><idno type="wicri:Area/Istex/Checkpoint">000E68</idno><idno type="wicri:doubleKey">0885-3185:2009:Ponsen M:hyposmia:and:executive</idno><idno type="wicri:source">PubMed</idno><idno type="RBID">pubmed:19353591</idno><idno type="wicri:Area/PubMed/Corpus">001D76</idno><idno type="wicri:Area/PubMed/Curation">001D76</idno><idno type="wicri:Area/PubMed/Checkpoint">001D72</idno><idno type="wicri:Area/Ncbi/Merge">002601</idno><idno type="wicri:Area/Ncbi/Curation">002601</idno><idno type="wicri:Area/Ncbi/Checkpoint">002601</idno><idno type="wicri:Area/Main/Merge">002B27</idno><idno type="wicri:source">INIST</idno><idno type="RBID">Pascal:09-0257332</idno><idno type="wicri:Area/PascalFrancis/Corpus">000E77</idno><idno type="wicri:Area/PascalFrancis/Curation">001E42</idno><idno type="wicri:Area/PascalFrancis/Checkpoint">000E45</idno><idno type="wicri:doubleKey">0885-3185:2009:Ponsen M:hyposmia:and:executive</idno><idno type="wicri:Area/Main/Merge">002F42</idno><idno type="wicri:Area/Main/Curation">002266</idno><idno type="wicri:Area/Main/Exploration">002266</idno></publicationStmt><sourceDesc><biblStruct><analytic><title level="a" type="main" xml:lang="en">Hyposmia and executive dysfunction as predictors of future Parkinson's disease: A prospective study</title><author><name sortKey="Ponsen, Mirthe M" sort="Ponsen, Mirthe M" uniqKey="Ponsen M" first="Mirthe M." last="Ponsen">Mirthe M. Ponsen</name><affiliation wicri:level="3"><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Neurology, VU University Medical Center, Amsterdam</wicri:regionArea><placeName><settlement type="city">Amsterdam</settlement><region nuts="2" type="province">Hollande-Septentrionale</region></placeName></affiliation></author><author><name sortKey="Stoffers, Diederick" sort="Stoffers, Diederick" uniqKey="Stoffers D" first="Diederick" last="Stoffers">Diederick Stoffers</name><affiliation wicri:level="3"><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Neurology, VU University Medical Center, Amsterdam</wicri:regionArea><placeName><settlement type="city">Amsterdam</settlement><region nuts="2" type="province">Hollande-Septentrionale</region></placeName></affiliation><affiliation wicri:level="3"><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Clinical Neuropsychology, VU University, Amsterdam</wicri:regionArea><placeName><settlement type="city">Amsterdam</settlement><region nuts="2" type="province">Hollande-Septentrionale</region></placeName></affiliation></author><author><name sortKey="Twisk, Jos W R" sort="Twisk, Jos W R" uniqKey="Twisk J" first="Jos W. R." last="Twisk">Jos W. R. Twisk</name><affiliation wicri:level="3"><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Clinical Epidemiology and Biostatistics, VU University, Amsterdam</wicri:regionArea><placeName><settlement type="city">Amsterdam</settlement><region nuts="2" type="province">Hollande-Septentrionale</region></placeName></affiliation></author><author><name sortKey="Wolters, Erik Ch" sort="Wolters, Erik Ch" uniqKey="Wolters E" first="Erik Ch." last="Wolters">Erik Ch. Wolters</name><affiliation wicri:level="3"><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Neurology, VU University Medical Center, Amsterdam</wicri:regionArea><placeName><settlement type="city">Amsterdam</settlement><region nuts="2" type="province">Hollande-Septentrionale</region></placeName></affiliation></author><author><name sortKey="Berendse, Henk W" sort="Berendse, Henk W" uniqKey="Berendse H" first="Henk W." last="Berendse">Henk W. Berendse</name><affiliation wicri:level="3"><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Neurology, VU University Medical Center, Amsterdam</wicri:regionArea><placeName><settlement type="city">Amsterdam</settlement><region nuts="2" type="province">Hollande-Septentrionale</region></placeName></affiliation></author></analytic><monogr></monogr><series><title level="j">Movement Disorders</title><title level="j" type="abbrev">Mov. Disord.</title><idno type="ISSN">0885-3185</idno><idno type="eISSN">1531-8257</idno><imprint><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>Hoboken</pubPlace><date type="published" when="2009-05-15">2009-05-15</date><biblScope unit="vol">24</biblScope><biblScope unit="issue">7</biblScope><biblScope unit="page" from="1060">1060</biblScope><biblScope unit="page" to="1065">1065</biblScope></imprint><idno type="ISSN">0885-3185</idno></series><idno type="istex">2BE542FF53E743C869DC1F5D9BBB5E50979EFEA0</idno><idno type="DOI">10.1002/mds.22534</idno><idno type="ArticleID">MDS22534</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0885-3185</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Aged</term><term>Asymptomatic</term><term>Cognition</term><term>Cognition Disorders (etiology)</term><term>Cognitive disorder</term><term>Diagnosis</term><term>Family Health</term><term>Female</term><term>Humans</term><term>Longitudinal Studies</term><term>Male</term><term>Middle Aged</term><term>Nervous system diseases</term><term>Neurologic Examination</term><term>Neuropsychological Tests</term><term>Olfaction</term><term>Olfaction Disorders (complications)</term><term>Olfactory disorder</term><term>Parkinson Disease (diagnosis)</term><term>Parkinson Disease (etiology)</term><term>Parkinson disease</term><term>Parkinson's disease</term><term>Predictive Value of Tests</term><term>Problem Solving (physiology)</term><term>Prospective</term><term>Regression Analysis</term><term>cognition</term><term>early diagnosis</term><term>olfaction</term><term>preclinical period</term></keywords><keywords scheme="MESH" qualifier="complications" xml:lang="en"><term>Olfaction Disorders</term></keywords><keywords scheme="MESH" qualifier="diagnosis" xml:lang="en"><term>Parkinson Disease</term></keywords><keywords scheme="MESH" qualifier="etiology" xml:lang="en"><term>Cognition Disorders</term><term>Parkinson Disease</term></keywords><keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Problem Solving</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Aged</term><term>Family Health</term><term>Female</term><term>Humans</term><term>Longitudinal Studies</term><term>Male</term><term>Middle Aged</term><term>Neurologic Examination</term><term>Neuropsychological Tests</term><term>Predictive Value of Tests</term><term>Regression Analysis</term></keywords><keywords scheme="Pascal" xml:lang="fr"><term>Asymptomatique</term><term>Cognition</term><term>Diagnostic</term><term>Maladie de Parkinson</term><term>Olfaction</term><term>Pathologie du système nerveux</term><term>Prospective</term><term>Trouble cognitif</term><term>Trouble de l'odorat</term></keywords><keywords scheme="Wicri" type="topic" xml:lang="fr"><term>Prospective</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Olfactory deficits and executive dysfunction are early and common symptoms in Parkinson's disease (PD). Previous studies have shown that hyposmia can be a first sign of PD. The aim of the present study was to determine which of three olfactory tests and two selected tests of executive function would be the best predictor of future PD over a 5 year period. In a cohort of 361 nonparkinsonian, nondemented first‐degree relatives of PD patients, in whom alternative causes of olfactory dysfunction were excluded, we measured baseline performance on three olfactory and two executive function tasks. Five years from baseline, clinical neurological evaluation and/or a screening questionnaire, sensitive to the presence of Parkinsonism, were used to detect individuals developing clinical PD. Our results show that in first degree relatives of PD patients worse performance on each of three olfactory processing tasks was associated with an increased risk of developing PD within 5 years, whereas performance on selected tests of executive dysfunction was not associated with an increased risk of developing PD. Interestingly, impaired odor discrimination was the best predictor for future PD. © 2009 Movement Disorder Society</div></front></TEI><affiliations><list><country><li>Pays-Bas</li></country><region><li>Hollande-Septentrionale</li></region><settlement><li>Amsterdam</li></settlement></list><tree><country name="Pays-Bas"><region name="Hollande-Septentrionale"><name sortKey="Ponsen, Mirthe M" sort="Ponsen, Mirthe M" uniqKey="Ponsen M" first="Mirthe M." last="Ponsen">Mirthe M. Ponsen</name></region><name sortKey="Berendse, Henk W" sort="Berendse, Henk W" uniqKey="Berendse H" first="Henk W." last="Berendse">Henk W. Berendse</name><name sortKey="Stoffers, Diederick" sort="Stoffers, Diederick" uniqKey="Stoffers D" first="Diederick" last="Stoffers">Diederick Stoffers</name><name sortKey="Stoffers, Diederick" sort="Stoffers, Diederick" uniqKey="Stoffers D" first="Diederick" last="Stoffers">Diederick Stoffers</name><name sortKey="Twisk, Jos W R" sort="Twisk, Jos W R" uniqKey="Twisk J" first="Jos W. R." last="Twisk">Jos W. R. Twisk</name><name sortKey="Wolters, Erik Ch" sort="Wolters, Erik Ch" uniqKey="Wolters E" first="Erik Ch." last="Wolters">Erik Ch. Wolters</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Santé/explor/MovDisordV3/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 002266 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 002266 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Wicri/Santé
|area= MovDisordV3
|flux= Main
|étape= Exploration
|type= RBID
|clé= ISTEX:2BE542FF53E743C869DC1F5D9BBB5E50979EFEA0
|texte= Hyposmia and executive dysfunction as predictors of future Parkinson's disease: A prospective study
}}
| This area was generated with Dilib version V0.6.23. |  |